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Ellagic Acid
And Nature’s Way to Battle Cancer Ellagic acid is a naturally occurring phenolic constituent in certain fruits and nuts. With highest concentrations in red raspberries, ellagic acid has been proven an effective anti-mutagen, anti-carcinogen, and inhibitor of cancer. Research at the Hollings Cancer Center at the Medical University of South Carolina (MUSC) indicate that ellagic acid slows the growth of abnormal colon cells in humans, prevents the development of cells infected with human papilloma virus (HPV), which is linked to cervical cancer, and promotes apoptotic growth (natural death) of prostate cancer cells. The apoptotic process triggered by this antioxidant also has beneficial effects on breast, lung, esophageal, and skin cancer (melanoma). Dr. Daniel Nixon, MUSC, began studying the ellagic acid in red raspberries in 1993. His recently published results show: Cervical Cancer Cells — HPV (human papilloma virus) exposed
to ellagic acid from red raspberries experienced apoptosis (normal
cell death). The availability to the body of ellagic acid from dietary sources
has only been confirmed with red raspberries. Other foods such as strawberries,
pomegranates, and walnuts contain ellagic acid yet the bioavailability
has not been confirmed.
Ellagic Acid Scientific Breakthrough! Ellagic Acid is astounding cancer researchers worldwide
with it's ability to apparently prevent many types of cancer cells
from multiplying, thus causing the cancer to die Ellagic Acid is a naturally occurring polyphenolic constituent found in 46 different fruits and nuts, like pomegranate, red raspberry, strawberry, blueberry and walnuts. Ellagic Acid may be one the most potent ways to fight Cancer. Ellagic Acid, a phenolic compound, inhibits the growth of cancer cells and arrests the growth in persons with a genetic predisposition for the disease. Ellagic Acid Study! The Hollings Cancer Institute at the University of South Carolina has conducted a double blind study on a group of 500 cervical cancer patients that had everyone excited. Nine years of study have shown that a natural product called Ellagic acid is causing G-arrest within 48 hours (inhibiting and stopping mitosis-cancer cell division), and apoptosis (normal cell death) within 72 hours, for breast, pancreas, esophageal, skin, colon and prostate cancer cells. Ellagic Acid Clinical Tests on cultured human cells also show that
Ellagic acid prevents the destruction of the p53 gene by cancer cells.
Additional studies suggest that one of the mechanisms by which Ellagic
acid inhibits mutagenesis and carcinogenesis is by forming adducts
with DNA, thus masking binding sites to be occupied by the mutagen
or carcinogen. Ellagic acid can be found in different foods. Other USA sources substantiate the Hollings Cancer Institute include: Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, Illinois; Division of Environmental Health Sciences, The Ohio State University The Ohio State University School of Public Health, Colombus, Ohio; Department of Medicine, Lakeside Veterans Affairs Medical Center, Northwestern University School of Medicine, Stanford, CA; Department of Preventative Medicine, Ohio State University, Colombus, Ohio. Here is a description of the study which came from a website of the Washington Raspberry Commission. You can see the Hollings research articles there. Here are some notes from the site. Reprinted by permission from WRC "The proposed study, under the direction of Daniel Nixon, M.D., President of the American Health Foundation and Drs. Dave Gangemi and Blair Holliday of the Hollings Cancer Center/Medical University of South Carolina, will evaluate women with atypical squamous cells of undetermined significance (ASCUS) in which there is neither treatment nor clinical evaluation available. ASCUS represents as much as 10% of all Papanicolaou smears in the US and represents approximately 5 million females. In this population, these women who are infected with human papillomaviruses (HPV) types 16 and/or 18 are at the greatest risk of developing cervical cancer at some stage in their lives. In addition, women who are diagnosed with the immature metaplastic form of ASCUS usually have lesions which are higher in the endocervical canal, are more metabolically active, have flatter surface areas, and are more likely to invade the underlying connective tissue as well as the endocervical glandular epithelium. This population represents approximately one million women in the United States alone. The condition is very pronounced in countries outside the United States. In India this is one of the two major cancers affecting women." Research sources: Cancer Lett 1999 Mar 1 1;136(2):215-21 "Ellagic acid is a phenolic compound present in fruits and nuts including raspberries, strawberries and walnuts. It is known to inhibit certain carcinogen-induced cancers and may have other chemopreventive properties. The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells. We found that ellagic acid at a concentration of 10(-5) M induced G arrest within 48 h, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 h of treatment. Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acin in cell cycle regulation of cancer cells." Focus: To Evaluate Red Raspberry Ellagic Acid in Prevention of Cervical Cancer There is now clinical evidence to suggest that ellagic acid concentrations at tissue sites such as the cervix may be obtained with the oral administration of red raspberries. This belief comes from bioavailability studies in which human volunteers have ingested raspberry puree. Because of this and observations in human volunteers ingesting daily quantities of raspberry puree for prevention of colon cancer, a clinical trial will examine ellagic acid from raspberries in prevention of pre-cancerous cervical lesions developing into a malignant condition. The proposed study, under the direction of Daniel Nixon, M.D., President of the American Health Foundation and Drs. Dave Gangemi and Blair Holliday of the Hollings Cancer Center/Medical University of South Carolina, will evaluate women with atypical squamous cells of undetermined significance (ASCUS) in which there is neither treatment nor clinical evaluation available. ASCUS represents as much as 10% of all Papanicolaou smears in the US and represents approximately 5 million females. In this population, these women who are infected with human papillomaviruses (HPV) types 16 and/or 18 are at the greatest risk of developing cervical cancer at some stage in their lives. In addition, women who are diagnosed with the immature metaplastic form of ASCUS usually have lesions which are higher in the endocervical canal, are more metabolically active, have flatter surface areas, and are more likely to invade the underlying connective tissue as well as the endocervical glandular epithelium. This population represents approximately one million women in the United States alone. The condition is very pronounced in countries outside the United States. In India this is one of the two major cancers affecting women. One way to evaluate the potential progression rate in these individuals is to monitor the levels of viral oncogene (E6/E7) messenger RNA expression in cervical tissue. The study with evaluate women with ASCUS who have little or no viral oncogene expression with those who have relatively elevated levels of HPV oncogene expression. The Study Approach & Red Raspberry Dosage The approach will orally administer ellagic acid (using red raspberry puree, the primary whole foods source of ellagic acid) at dosages providing detectable tissue levels in the cervix (Phase I of proposed study) over a two-year period (Phase II). Women in the study (to commence 1999-2000) will be carefully evaluated for any potential adverse effects of treatment and their E6/E7 levels carefully monitored every three months. Women receiving treatment will then undergo a full clinical evaluation at the end of the two-year trial period and changes in the levels of oncogene expression and in cervical pathology determined. Changes in women receiving the red raspberry dosage will be compared to changes in women receiving a placebo. A biostatistician will evaluate the group sizes needed to determine a statistically significant change in ASCUS progression following ellagic acid (red raspberry) ingestion. Preliminary estimates indicate that five hundred women will be needed for the generation of valid predictions. Volunteers will be recruited from the MUSC Cancer Center Access Network, Clinics and the State Department of Health and Environmental Control. Entry will be based on pathological and cytological conditions discussed herein. Individuals will be divided into low and high HPV oncogene expression groups and each group further divided into ellagic acid and placebo groups. Phase I Study In Phase I, serum levels of ellagic acid will be monitored over a two-month period. At the end of this time cervical biopsies taken to determine tissue levels. Highly sensitive analytical techniques utilizing gas chromatographic mass spectroscopy will be utilized to measure tissue concentrations. The results from Phase I will be used to determine compliance rates and the daily dosage needed to detect ellagic acid in the cervix. Phase II Study In Phase II, cervical swabs will be taken from volunteers will well-defined cytopathological changes and the cells evaluated for HPV oncogene expression using a highly sensitive biomarkers assay (reverse transcriptase-polymerase chain reaction (RT-PCR). Individuals will receive oral dosages (to be determined from Phase I) of raspberry puree and be reevaluated every three months to determine the condition of their lesions (progressive, persistent, or regressive) using immunocytochemical techniques. Phase II will be a double blind placebo controlled study in which the research pharmacy laboratory will keep the treatment code. At the end of the two year period, date from each treatment group will be evaluated by a biostatistician and compared to placebo groups for changes in the rate of progression to Low Grade Cervical Intrepithelial Lesions (CINI). Any volunteer progressing to CINI during this study will be removed and given conventional therapy (colposcopy and biopsy, laser ablation, or loop excision of the transformation zone) A barrage of clinical research at Hollings Cancer Center (Charleston, SC) confirms that red raspberries, the richest food source of a substance known as ellagic acid, inhibits the growth of cancer cells. Studies under the direction of Dr. Daniel Nixon indicate that daily consumption of 150grams (1 cup) of red raspberries slows the growth of abnormal colon cells in humans, prevents (in some instances destroys) the development of cells infected with human papilloma virus (HPV) the cause of cervical cancer, and most recently found to break down extracted human leukemia cells. Dr. Nixon's anti-cancer prowess comes at a time when most Americans seek to treat medical problems through changes in diet, rather than take medication. Foods containing significant levels of biologically active components that impart health benefits beyond basic nutrition when consumed in typical or optimal serving sizes, are fast-becoming the hot button for consumers. Red raspberries as the key source of cancer preventive, cancer fighting, and in some instances cancer cell destroying ellagic acid may be the ultimate cancer-fighting food today. Food Sources of Ellagic Acid – micrograms/gm dry wt. Red Raspberries1500
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Cancer cells hide after Chemotherapy
and Radiation
After the initial doses of radiation and/or chemotherapy, cancer
cells start hiding.
" They develop a slime coating, and they become like Stealth
bombers, and they can hide from future doses of radiation and chemotherapy.
This is why repeated dose of radiation and chemotherapy become less effective".Dr.
John Maras, Nu-Gen Educational Library.
" The way to get rid of this "slime coating" is to
use large doses of plant and animal enzymes- especially bromelain and pancreatin.
This allows an 'access point' for the immune system to attack the cancer
cells".....Dr. John Maras, Nu-Gen Educational Library
What doctors say about Chemo Therapy
?
"The world is a dangerous
place to live; not because of the people who are evil, but because
of the people who don't do anything about it."
Albert Einstein A Sad day for Alternative healing  |
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NOTICE: Due to FDA TGA MOH (plus other institutions with a vestige interest) regulations and various state laws, no medical claims can be made for alternative therapys and technology. All of the information expressed herein must be considered theoretical and unproven and for experimental research only | |
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